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KMID : 0365819720120010175
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Journal of Pusan Medical College
1972 Volume.12 No. 1 p.175 ~ p.186
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Effect of Tracheobronchial Instillation of Human Amniotic Fluid on Pulmonary Surface Activity of Rabbit Lung
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Abstract
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The author studied the effect of tracheobronchial instillation of human amniotic fluid and human plasma solution on the static pressure-volume relationship and surface activity of lung extracts in rabbits and compared with normal controls.
The range of correlation was extended by treating such lungs with saline flushing or one atm. 100% oxygen breathing. It is concluded as follows.
1) In normal rabbits, the expansion index was 0.88±0.51 and the minimal surface tension of lung extract was 10. 7±1-31 dyne/cm with 1. 17±0.05 of extract stability index.
2) The rabbit lungs instilled with human amniotic fluid 3 ml/kg showed significantly decreased expansion index (0.60±0.041), and significantly increased minimal surface tension (20.5±1.76 dyne/cm with significantly decreased stability index (0. 67±0. 058).
3) The rabbit lung instilled with human plasma solution 3 ml/kg showed no significant difference with the lungs instilled with human amniotic fluid in expansion index of excised lung as well as in surface activity of lung extracts.
4) Saline flushing through bronchi after instillation of human amniotic fluid into the rabbit lung had failed to treat the effect of intra-alveolar human amniotic fluid on the surface activity and even more accentuated the decreasing of surface activity.
The prolonged breathing of one atm. 100% oxygen had no influence to alter the surface activity of the lungs instilled with amniotic fluid.
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